Menstrual Fluid May Aid in Endometriosis Detection - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Menstrual Fluid May Aid in Endometriosis Detection

Single-nucleus sequencing of menstrual fluid identified epithelial gene signatures and prioritized five candidate biomarkers that warrant validation in larger studies.

  • By

  • Andrea Surnit

  • July 13, 2026

  • 3 min

Share

  • 1

    Menstrual fluid from endometriosis patients shows distinct endometrial epithelial signatures detectable in RNA analysis.

  • 2

    A pilot study analyzed menstrual fluid from 5 endometriosis patients and 5 healthy controls using RNA sequencing.

  • 3

    The study identified 36 upregulated and 53 downregulated epithelial genes associated with endometriosis.

  • 4

    Five genes were differentially expressed in both single-nucleus and bulk RNA analyses, with KCNK5 as a potential biomarker.

  • 5

    The study's limitations include a small sample size and variability in menstrual fluid composition among donors.

Original Source(s)

Menstrual Fluid May Aid in Endometriosis Detection

  • by Andrea Surnit

  • July 13, 2026

Related Content

Could Pregnancy Complications Predict CVD Risk?

Investigators found that adding pregnancy-related and female-specific factors modestly improved postpartum cardiovascular risk prediction compared with traditional risk factors alone.

Pregnancy Risks With First Trimester GLP-1 Continuation

Claims-based target trial emulation found no clear association between continued GLP-1 receptor agonist use in early pregnancy and nonlive birth, fetal growth abnormalities, or major congenital malformations.

Deciphering immune-inflammatory dysregulation in the endometriotic microenvironment: insights from single-cell omics and artificial intelligence