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Childhood Trauma's Influence on Depressive Symptoms in Adolescents with Bipolar Disorder: The Role of Sleep Disturbance as a Mediator

  • By

  • Zhiying Wan

  • Yuan Hu

  • Yanfang Liu

  • Yue Sun

  • Zhongchun Liu

  • Meiyu Shen

  • Xiaofen Li

  • December 23, 2025

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  • 1

    Childhood trauma significantly exacerbates depressive symptoms in adolescents with bipolar disorder, impacting their overall progression and treatment response.

  • 2

    Sleep disturbances are prevalent among adolescents with bipolar disorder and are strongly correlated with the severity of depressive symptoms.

  • 3

    The study aims to investigate sleep disturbances as a mediator between childhood trauma and depressive symptoms in adolescents with bipolar disorder.

  • 4

    Adolescents with bipolar disorder often experience complex depressive episodes that lead to functional impairments and increased suicide risk.

  • 5

    Identifying sleep disturbances as a target for intervention may help mitigate depression in adolescents with a history of childhood trauma.

Original Source(s)

Impact of childhood trauma on depressive symptoms in bipolar adolescents: the mediating effect of sleep disturbance

  • by Zhiying Wan, Yuan Hu, Yanfang Liu, Yue Sun, Zhongchun Liu, Meiyu Shen, Xiaofen Li

  • December 23, 2025

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