Homocysteine and cognitive function in depression: a systematic review and meta-analysis - Takeaways - MDSpire

Homocysteine and cognitive function in depression: a systematic review and meta-analysis

  • By

  • Xiaotong Liu

  • Qingsong Liu

  • Jili Xu

  • Jie Wu

  • May 13, 2026

  • 0 min

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  • 1

    This systematic review and meta-analysis evaluated the relationship between homocysteine levels and cognitive function in depressed patients.

  • 2

    The analysis included 13 studies with 1,269 patients, revealing a significant inverse association between homocysteine levels and cognitive scores.

  • 3

    Higher homocysteine levels correlated with poorer cognitive performance, with patients showing cognitive impairment having notably elevated levels.

  • 4

    The findings suggest that homocysteine may serve as a biologically relevant marker for cognitive impairment in individuals with depression.

  • 5

    Further prospective studies are recommended to clarify the clinical significance of homocysteine in assessing cognitive impairment in depression.

Original Source(s)

Homocysteine and cognitive function in depression: a systematic review and meta-analysis

  • by Xiaotong Liu, Qingsong Liu, Jili Xu, Jie Wu

  • May 13, 2026

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