Invasive Pneumococcal Disease and Impact of 7- and 13-Valent Pneumococcal Conjugate Vaccines in Singapore Children Over 24 Years

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The overall incidence of invasive pneumococcal disease (IPD) in Singaporean children aged <17 years was 3.9 per 100,000 from 2000 to 2023.
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IPD incidence significantly declined in children aged ≤2 years from 13.3 to 4.7 per 100,000 after the introduction of pneumococcal conjugate vaccines.
3

IPD cases due to PCV7 serotypes decreased from 68% to 22%, while PCV13 serotypes declined from 80.5% to 70.2% from period 1 to period 2.
4

The proportion of IPD cases caused by serotype 19A increased dramatically from 6.5% to 38.7% after the implementation of PCV13.
5

The introduction of PCVs into Singapore's immunization schedule significantly reduced IPD burden, but serotype 19A remains a challenge.

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