Baicalin improves the inflammatory response of RA-FLS by targeting the circ_0000734/miR-197-5p/IKBKB axis - Takeaways - MDSpire

Baicalin improves the inflammatory response of RA-FLS by targeting the circ_0000734/miR-197-5p/IKBKB axis

  • By

  • Yanqiu Sun

  • Jian Liu

  • Mingyu He

  • Xiaolu Chen

  • May 28, 2026

  • 0 min

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  • 1

    Baicalin modulates inflammation in rheumatoid arthritis (RA) fibroblast-like synoviocytes via the circ_0000734/miR-197-5p/IKBKB pathway.

  • 2

    Circ_0000734 is highly expressed in RA patients and correlates positively with disease activity indicators such as RF, anti-CCP, CRP, ESR, and DAS28 scores.

  • 3

    Overexpression of circ_0000734 in TNF-α-stimulated RA-FLS promotes cell proliferation and activates the NF-κB pathway, enhancing inflammatory cytokine secretion.

  • 4

    Silencing circ_0000734 or overexpressing miR-197-5p reverses the effects of circ_0000734 on RA-FLS viability and inflammatory factor expression.

  • 5

    Baicalin treatment reduces circ_0000734 levels, inhibits NF-κB pathway activation, and improves the inflammatory cytokine profile in RA-FLS.

Original Source(s)

Baicalin improves the inflammatory response of RA-FLS by targeting the circ_0000734/miR-197-5p/IKBKB axis

  • by Yanqiu Sun, Jian Liu, Mingyu He, Xiaolu Chen

  • May 28, 2026

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