A comprehensive review and expression analysis of polymorphisms in DNA repair genes linked to leukemia - Takeaways - MDSpire

A comprehensive review and expression analysis of polymorphisms in DNA repair genes linked to leukemia

  • By

  • Honghui Ye

  • Jinyong Fang

  • Pei Jin

  • April 23, 2026

  • 0 min

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  • 1

    This study evaluates the association between DNA repair gene polymorphisms and leukemia risk, focusing on XP and XRCC genes.

  • 2

    Fifty-four studies were included in the meta-analysis, revealing significant associations for several polymorphisms with leukemia susceptibility.

  • 3

    Key polymorphisms associated with increased leukemia risk include XPD Lys751Gln, XPC Lys939Gln, XRCC1 Arg194Trp, XRCC1 Arg399Gln, and XRCC3 Thr241Met.

  • 4

    Gene expression analyses indicated subtype-specific alterations in DNA repair genes across different leukemia datasets.

  • 5

    The findings highlight the potential relevance of DNA repair gene polymorphisms in leukemia risk stratification and biomarker development.

Original Source(s)

A comprehensive review and expression analysis of polymorphisms in DNA repair genes linked to leukemia

  • by Honghui Ye, Jinyong Fang, Pei Jin

  • April 23, 2026

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