Mechanism of liposome arsenic trioxide regulating tumor microenvironment and sensitizing tumor immune response after radiofrequency ablation - Takeaways - MDSpire

Mechanism of liposome arsenic trioxide regulating tumor microenvironment and sensitizing tumor immune response after radiofrequency ablation

  • By

  • Chao Liang

  • Shuguang Ju

  • Hao Li

  • Daqian Han

  • Jiacheng Wang

  • Yangyang Niu

  • Jianzhuang Ren

  • Xinwei Han

  • Xuhua Duan

  • June 29, 2026

  • 0 min

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  • 1

    Preoperative administration of liposome arsenic trioxide (LATO) aims to downregulate HIF-1α in residual tumors after incomplete radiofrequency ablation (iRFA).

  • 2

    LATO significantly decreases the expression of PCNA, CD31, and HIF-1α in residual tumors, promoting immune cell infiltration and prolonging survival in mice.

  • 3

    The combination of LATO and anti-PD-L1 antibody therapy further reduces tumor proliferation and enhances the antitumor immune response post-ablation.

  • 4

    Incomplete tumor necrosis after RFA is primarily due to factors like increased blood flow and energy deposition limitations within the tumor.

  • 5

    Liposomal drug delivery systems like LATO improve the therapeutic index of arsenic trioxide by enhancing tumor site deposition and reducing systemic toxicity.

Original Source(s)

Mechanism of liposome arsenic trioxide regulating tumor microenvironment and sensitizing tumor immune response after radiofrequency ablation

  • by Chao Liang, Shuguang Ju, Hao Li, Daqian Han, Jiacheng Wang, Yangyang Niu, Jianzhuang Ren, Xinwei Han, Xuhua Duan

  • June 29, 2026

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