Deep brain stimulation of the hypothalamic region: a systematic review

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The hypothalamus, a small but complex brain region, regulates vital neuroendocrine, behavioral, and autonomic processes.
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Deep brain stimulation (DBS) targeting the hypothalamus has been used since 1970 to treat various psychological and neurological conditions.
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A systematic review identified 34 studies involving 412 patients, focusing on the effects of DBS on hypothalamic regions.
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Refractory chronic headaches and aggressive behavior were the most common indications for hypothalamic DBS in the reviewed studies.
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The posterior hypothalamus was the most frequently targeted area for DBS, particularly for treating chronic headaches.

Acta Neurochirurgica

by Mohammad Mofatteh, Abdulkadir Mohamed, Mohammad Sadegh Mashayekhi, Georgios P. Skandalakis, Clemens Neudorfer, Saman Arfaie, ArunSundar MohanaSundaram, Mohammadmahdi Sabahi, Ayush Anand, Rabii Aboulhosn, Xuxing Liao, Andreas Horn, Keyoumars Ashkan
February 4, 2025

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