Short-course versus long-course antibiotics in bone infections: a meta-analysis of randomised controlled trials - Takeaways - MDSpire
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Comparing Short- and Long-Duration Antibiotic Therapy for Bone Infections: A Meta-Analysis of Randomized Controlled Trials

  • By

  • Yang Sun

  • Yu Sun

  • Zhaolun Feng

  • Bo Hakert

  • Jiantong Ma

  • Jillian Cornish

  • October 19, 2026

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  • 1

    The meta-analysis compared short- and long-course antibiotic therapy for bacterial bone infections using randomized controlled trials.

  • 2

    The authors planned parallel intention-to-treat and per-protocol analyses to address limitations of earlier meta-analyses.

  • 3

    Treatment failure was the primary outcome and included recurrence, persistent infection, or an unplanned additional intervention.

  • 4

    Antibiotic-related adverse events were also evaluated as an outcome.

  • 5

    The review searched four databases from inception through February 2026 and followed PRISMA guidance.

Original Source(s)

Short-course versus long-course antibiotics in bone infections: a meta-analysis of randomised controlled trials

  • by Yang Sun, Yu Sun, Zhaolun Feng, Bo Hakert, Jiantong Ma, Jillian Cornish

  • October 19, 2026

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