Approaches to Implementing Cascade Genetic Testing: Attention to Detail Matters

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Nearly 2 million individuals in the US face elevated lifetime risk of inherited genetic conditions, including HBOC and Lynch syndrome.
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A multicenter investigation found that 12.5% of cancer patients harbored a germline pathogenic variant in moderate- or high-penetrance cancer genes.
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Cascade genetic testing among at-risk relatives remains suboptimal, with low testing rates even in families with documented cancer history.
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The IGNITE-TX study demonstrated feasibility in engaging a diverse patient population for cascade genetic testing using digital platforms.
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Enrollment in the IGNITE-TX study included only 20% of eligible patients, highlighting challenges in reaching broader populations.

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