The DLEU2/miR-15a/miR-16-1 cluster shapes the immune microenvironment of chronic lymphocytic leukemia - Takeaways - MDSpire

The DLEU2/miR-15a/miR-16-1 cluster shapes the immune microenvironment of chronic lymphocytic leukemia

  • By

  • Ronghua Zhang

  • Priyanka Khare

  • Priyanka Banerjee

  • Cristina Ivan

  • Sarah Schneider

  • Federica Barbaglio

  • Karen Clise-Dwyer

  • Vanessa Behrana Jensen

  • Erika Thompson

  • Marisela Mendoza

  • Nicholas Chiorazzi

  • Shih-Shih Chen

  • Xiao-Jie Joy Yan

  • Nitin Jain

  • Paolo Ghia

  • Federico Caligaris-Cappio

  • Rima Mendonsa

  • Sashi Kasimsetty

  • Ryan Swoboda

  • Recep Bayraktar

  • William Wierda

  • Varsha Gandhi

  • George A. Calin

  • Michael J. Keating

  • Maria Teresa Sabrina Bertilaccio

  • October 23, 2024

  • 0 min

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  • 1

    Chronic lymphocytic leukemia (CLL) is characterized by the expansion of CD5+ B cells and is often associated with chromosomal alterations.

  • 2

    The DLEU2/miR-15a/miR-16-1 cluster plays a critical role in CLL pathogenesis by targeting the bcl-2 oncogene, acting as a tumor suppressor.

  • 3

    The immune microenvironment in CLL is populated by various immune cells that provide survival signals to malignant cells and suppress immune responses.

  • 4

    BCL2 overexpression in CLL is linked to impaired apoptosis and activation of pathways that promote leukemic cell survival.

  • 5

    This study reveals the involvement of the DLEU2/miR-15a/miR-16-1 cluster in the protumor function of non-malignant immune cells in CLL.

Original Source(s)

The DLEU2/miR-15a/miR-16-1 cluster shapes the immune microenvironment of chronic lymphocytic leukemia

  • by Ronghua Zhang, Priyanka Khare, Priyanka Banerjee, Cristina Ivan, Sarah Schneider, Federica Barbaglio, Karen Clise-Dwyer, Vanessa Behrana Jensen, Erika Thompson, Marisela Mendoza, Nicholas Chiorazzi, Shih-Shih Chen, Xiao-Jie Joy Yan, Nitin Jain, Paolo Ghia, Federico Caligaris-Cappio, Rima Mendonsa, Sashi Kasimsetty, Ryan Swoboda, Recep Bayraktar, William Wierda, Varsha Gandhi, George A. Calin, Michael J. Keating, Maria Teresa Sabrina Bertilaccio

  • October 23, 2024

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