Genomic Structural Variations in Bacteria Linked to Autism in Children as Potential Diagnostic Indicators

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The study identified 100 bacterial genomic structural variations (SVs) significantly associated with autism spectrum disorder (ASD).
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Distinct bacterial SV signatures linked to ASD were associated with metabolic dysregulation and gut dysbiosis commonly observed in affected children.
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Critical SVs in Bacteroides uniformis were shown to regulate thiamine and iron metabolism, correlating with ASD-related behaviors.
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A diagnostic panel combining nine SVs and three bacterial species achieved an accuracy of 81.1% in distinguishing ASD from neurotypical children.
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The findings suggest potential for microbial genomic SV-based biomarkers in diagnosing childhood ASD and understanding its pathogenesis.

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