Spectral computed tomography characterization of coronary atherosclerotic plaque: principles, imaging biomarkers, and clinical significance - Takeaways - MDSpire

Spectral computed tomography characterization of coronary atherosclerotic plaque: principles, imaging biomarkers, and clinical significance

  • By

  • Yujian Liu

  • Yu Peng

  • Hao Wu

  • Yuan Li

  • May 29, 2026

  • 0 min

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  • 1

    Coronary atherosclerotic plaque vulnerability is influenced by composition, calcification, inflammation, and microenvironmental changes.

  • 2

    Spectral CT enhances plaque assessment by utilizing multi-energy information and material decomposition, surpassing single-energy imaging limitations.

  • 3

    Recent studies indicate spectral CT improves characterization of calcified lesions and quantification of high-risk plaque burden.

  • 4

    Current evidence shows spectral CT's clinical value lies in accurate assessment and better decision-making, despite barriers to broader implementation.

  • 5

    The future of spectral CT in clinical practice depends on hardware improvements, standardization, and validation within risk assessment frameworks.

Original Source(s)

Spectral computed tomography characterization of coronary atherosclerotic plaque: principles, imaging biomarkers, and clinical significance

  • by Yujian Liu, Yu Peng, Hao Wu, Yuan Li

  • May 29, 2026

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