DNER drives glycolytic reprogramming in renal cell carcinoma by activating the JAK2/STAT3 signaling pathway - Takeaways - MDSpire

DNER drives glycolytic reprogramming in renal cell carcinoma by activating the JAK2/STAT3 signaling pathway

  • By

  • Anrui Li

  • Jing-wen Xu

  • Jian-hua Qin

  • Qi Yuan

  • Lichen Teng

  • May 22, 2026

  • 0 min

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  • 1

    DNER is identified as a hub gene linked to metabolic pathway activity and immune cell infiltration in clear cell renal cell carcinoma (ccRCC).

  • 2

    DNER promotes ccRCC cell proliferation through activation of the JAK2/STAT3 signaling pathway, enhancing glycolytic flux and lactate production.

  • 3

    Increased lactate production from DNER activity drives macrophage polarization toward a pro-tumorigenic M2-like phenotype.

  • 4

    DNER overexpression may correlate with enhanced sensitivity of ccRCC cells to the PARP inhibitor Olaparib, requiring further investigation.

  • 5

    The study highlights the role of DNER in linking metabolic reprogramming to immunosuppressive microenvironment remodeling in ccRCC.

Original Source(s)

DNER drives glycolytic reprogramming in renal cell carcinoma by activating the JAK2/STAT3 signaling pathway

  • by Anrui Li, Jing-wen Xu, Jian-hua Qin, Qi Yuan, Lichen Teng

  • May 22, 2026

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