Multiniche mycobiome profiling identifies distinctive fungal dysbiosis in common variable immunodeficiency - Takeaways - MDSpire

Multiniche mycobiome profiling identifies distinctive fungal dysbiosis in common variable immunodeficiency

  • By

  • Marta Dafne Cabanero-Navalon

  • Miguel Carda-Diéguez

  • Alex Mira

  • Pedro Moral Moral

  • Maria Mercedes Diaz Luna

  • Héctor Balastegui-Martín

  • Miguel Salavert Lletí

  • Victor Garcia-Bustos

  • May 20, 2026

  • 0 min

Share

  • 1

    CVID patients exhibit significant mycobiome composition differences compared to healthy controls, with reduced fungal richness and evenness.

  • 2

    A 'Candida-skewed' mycobiome configuration is observed in CVID, particularly with increased Candida albicans and other opportunistic yeasts.

  • 3

    Machine learning models based on fungal profiles can effectively distinguish CVID patients from healthy controls, achieving high AUC values.

  • 4

    The study highlights the potential role of opportunistic yeasts as pathobionts in CVID, suggesting their relevance in disease mechanisms.

  • 5

    Findings support the exploration of fungal signatures as non-invasive biomarkers for CVID, enhancing understanding of immune dysregulation.

Original Source(s)

Multiniche mycobiome profiling identifies distinctive fungal dysbiosis in common variable immunodeficiency

  • by Marta Dafne Cabanero-Navalon, Miguel Carda-Diéguez, Alex Mira, Pedro Moral Moral, Maria Mercedes Diaz Luna, Héctor Balastegui-Martín, Miguel Salavert Lletí, Victor Garcia-Bustos

  • May 20, 2026

Related Content

Necrotizing Fasciitis Following Minor Bike Injury

Rapid progression from superficial abrasions to septic shock highlights diagnostic challenges and need for prompt multidisciplinary care.

Limits of Negative Infection Studies in AD

Perspective argues that study design and measurement challenges may obscure potential links between infection and disease

Remodeling mechanisms and intervention strategies of the oral mucosal immune barrier