Ga-68 FAPI-04 PET/CT detection of repeatedly biopsy-negative poorly differentiated gastric adenocarcinoma: a case report - Takeaways - MDSpire

Detection of Poorly Differentiated Gastric Adenocarcinoma Using Ga-68 FAPI-04 PET/CT in a Case with Repeatedly Negative Biopsies

  • By

  • Zhipeng Cheng

  • Xiuxiu Chang

  • Yuying Lei

  • Na Liu

  • Jing Wu

  • Lifei Zhang

  • Aixia Sui

  • July 17, 2026

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  • 1

    A 56-year-old man with progressive symptoms had three negative endoscopic biopsies before undergoing Ga-68 FAPI-04 PET/CT.

  • 2

    Ga-68 FAPI-04 PET/CT showed intense uptake and clearer lesion delineation compared to F-18 FDG PET/CT.

  • 3

    The patient underwent distal gastrectomy due to progressive gastric outlet obstruction and persistent suspicion of malignancy.

  • 4

    Final histopathology confirmed poorly differentiated gastric adenocarcinoma with partial signet-ring cell morphology.

  • 5

    The patient received postoperative XELOX chemotherapy and remained clinically stable at the 7-month follow-up.

Original Source(s)

Ga-68 FAPI-04 PET/CT detection of repeatedly biopsy-negative poorly differentiated gastric adenocarcinoma: a case report

  • by Zhipeng Cheng, Xiuxiu Chang, Yuying Lei, Na Liu, Jing Wu, Lifei Zhang, Aixia Sui

  • July 17, 2026

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