Intracranial mesenchymal tumor with FET::CREB fusion: a rare case report - Takeaways - MDSpire

Intracranial mesenchymal tumor with FET::CREB fusion: a rare case report

  • By

  • Weina Ma

  • Tianping Li

  • Yahui Yi

  • June 18, 2026

  • 0 min

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  • 1

    This case report discusses a rare intracranial mesenchymal tumor with FET::CREB fusion, highlighting diagnostic challenges and recurrence.

  • 2

    A 58-year-old female presented with a persistent headache and was found to have a cystic mass in the right temporoparietal lobe.

  • 3

    Histopathological analysis confirmed the tumor's identity, showing positivity for Desmin, MUC4, CD99, and ALK, alongside an EWSR1::ATF1 fusion.

  • 4

    The patient experienced tumor recurrence two years post-surgery, necessitating a second gross total resection.

  • 5

    The report emphasizes the need for molecular profiling in diagnosing this tumor type and the potential for recurrence despite treatment.

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