Single dose of 5 Gy can damage erythrocytes and consequently induces lymphocyte depletion in spleen and circulating blood - Takeaways - MDSpire

Single dose of 5 Gy can damage erythrocytes and consequently induces lymphocyte depletion in spleen and circulating blood

  • By

  • Peimeng You

  • Xiaohang Qin

  • Yinghui Li

  • Huiling Ye

  • Yuhui Zhao

  • Guangshan Wang

  • Cuimeng Tian

  • Shuo Yin

  • Junyu Li

  • Teng Ma

  • Feng-Ming (Spring) Kong

  • Jian-Yue Jin

  • June 19, 2026

  • 0 min

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  • 1

    A single exposure to 5 Gy radiation causes morphological damage to erythrocytes, as evidenced by changes observed post-irradiation.

  • 2

    Irradiated erythrocytes are phagocytosed in the spleen, leading to an increase in hemosiderin-laden macrophages in the red pulp.

  • 3

    The study found a significant depletion of B lymphocytes in peripheral blood and both T and B lymphocytes in the spleen following irradiation.

  • 4

    Radiation-induced lymphopenia (RIL) is associated with poor patient prognosis and is linked to the depletion of lymphocytes during radiotherapy.

  • 5

    The research supports the hypothesis that erythrocyte damage from radiation may indirectly contribute to lymphocyte depletion in the spleen.

Original Source(s)

Single dose of 5 Gy can damage erythrocytes and consequently induces lymphocyte depletion in spleen and circulating blood

  • by Peimeng You, Xiaohang Qin, Yinghui Li, Huiling Ye, Yuhui Zhao, Guangshan Wang, Cuimeng Tian, Shuo Yin, Junyu Li, Teng Ma, Feng-Ming (Spring) Kong, Jian-Yue Jin

  • June 19, 2026

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