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Postop Pain Differs by Vitamin D Status

Patients with preoperative vitamin D deficiency had higher postoperative pain scores and opioid use after mastectomy, including more than triple the odds of moderate to severe pain within 24 hours of surgery.

  • By

  • Kathryn Wighton

  • May 27, 2026

  • 3 min

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  • 1

    Vitamin D deficiency in breast cancer surgery patients is linked to higher rates of moderate to severe pain at 12 hours post-surgery.

  • 2

    In the study, 17% of vitamin D-deficient patients reported moderate to severe pain compared to 2% of vitamin D-sufficient patients at 12 hours.

  • 3

    Cumulative pain scores during the first 24 hours were higher in vitamin D-deficient patients, with greater postoperative tramadol consumption.

  • 4

    Vitamin D deficiency was associated with over three times the odds of experiencing moderate to severe postoperative pain after adjustments.

  • 5

    The study's limitations include a single-center design, short follow-up, and lack of assessment of various potential confounding factors.

Original Source(s)

Postop Pain Differs by Vitamin D Status

  • by Kathryn Wighton

  • May 27, 2026

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