Extracellular vesicle signalling in perioperative neurocognitive disorders

1

Perioperative neurocognitive disorders (PND) significantly impact older surgical patients, leading to prolonged hospitalization and worse long-term outcomes.
2

PND is driven by multiple interacting mechanisms, including systemic inflammation, blood-brain barrier injury, and neurovascular dysfunction.
3

Extracellular vesicles (EVs) serve as a potential link between peripheral stress and postoperative brain dysfunction, carrying diverse biological signals.
4

Clinical studies indicate that EV cargo correlates with postoperative delirium and cognitive outcomes, highlighting their relevance in PND research.
5

Understanding EV signaling may enhance insights into PND mechanisms and improve biomarker development for perioperative cognitive health.

1