The Association Between Depression and Gastro-Oesophageal Reflux Disease (GERD): Findings from the UK Biobank Analysis - Takeaways - MDSpire

The Association Between Depression and Gastro-Oesophageal Reflux Disease (GERD): Findings from the UK Biobank Analysis

  • By

  • Julia Reizner

  • Dennis Freuer

  • Timo Schmitz

  • Jakob Linseisen

  • Christa Meisinger

  • January 8, 2026

  • 0 min

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  • 1

    GERD affects 10–25% of the Western population, caused by improper closure of the lower oesophageal sphincter.

  • 2

    Depression is suggested as a potential risk factor for developing GERD, with rising prevalence in the European population.

  • 3

    The UK Biobank study included 457,958 participants to investigate the association between depression and incident GERD.

  • 4

    Depression was defined using ICD-10 codes, focusing on depressive episodes without including chronic cases.

  • 5

    Statistical analyses included Cox regression models adjusted for various covariables to assess the risk of GERD in depressed individuals.

Original Source(s)

The Association Between Depression and Gastro-Oesophageal Reflux Disease (GERD): Findings from the UK Biobank Analysis

  • by Julia Reizner, Dennis Freuer, Timo Schmitz, Jakob Linseisen, Christa Meisinger

  • January 8, 2026

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