An atlas on multitudinous risk factors associated with incident hypertension: comprehensive exposome-wide association and wide-angled genetic analyses - Takeaways - MDSpire

An atlas on multitudinous risk factors associated with incident hypertension: comprehensive exposome-wide association and wide-angled genetic analyses

  • By

  • Hongxi Yang

  • Yuhan Jiang

  • Ju Guo

  • Jianhua Wang

  • Xin Ma

  • Kexin Chen

  • Hua Yan

  • Ying Yu

  • Dandan Huang

  • July 18, 2024

  • 0 min

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  • 1

    This study constructed an atlas of risk factors for hypertension using exposome-wide association studies (ExWAS) and genetic analyses.

  • 2

    A total of 214,957 UK Biobank participants were analyzed, identifying 964 significant exposome variables related to hypertension.

  • 3

    Meta-analyses confirmed 462 exposome variables with strong evidence linking them to hypertension risk.

  • 4

    Mendelian randomization analyses provided robust causal evidence for 125 phenotypes associated with hypertension.

  • 5

    The findings highlight modifiable lifestyle factors, such as television watching and walking pace, as targets for hypertension prevention.

Original Source(s)

An atlas on multitudinous risk factors associated with incident hypertension: comprehensive exposome-wide association and wide-angled genetic analyses

  • by Hongxi Yang, Yuhan Jiang, Ju Guo, Jianhua Wang, Xin Ma, Kexin Chen, Hua Yan, Ying Yu, Dandan Huang

  • July 18, 2024

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