Risks of Opioid Overdose Linked to Concurrent Use of Hydrocodone and SSRIs - Takeaways - MDSpire

Risks of Opioid Overdose Linked to Concurrent Use of Hydrocodone and SSRIs

  • By

  • Sungho Bea

  • Krista F. Huybrechts

  • Robert J. Glynn

  • Seanna M. Vine

  • Shruti Belitkar

  • Brian T. Bateman

  • Katsiaryna Bykov

  • November 28, 2025

  • 0 min

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  • 1

    Opioids, including hydrocodone, pose significant risks such as dependence and overdose, with 294,000 deaths linked to prescribed opioids in the US from 1999 to 2022.

  • 2

    SSRIs, commonly prescribed for depression, can interact with opioids like hydrocodone, potentially increasing the risk of opioid overdose.

  • 3

    The study evaluated the risk of opioid overdose among patients using hydrocodone who initiated treatment with five different SSRIs.

  • 4

    Patients were monitored for opioid overdose through hospitalizations or emergency visits, using ICD-9 and ICD-10 codes for accurate identification.

  • 5

    The findings aim to clarify whether specific SSRIs increase overdose risk when used concurrently with hydrocodone, addressing a critical public health concern.

Original Source(s)

Risks of Opioid Overdose Linked to Concurrent Use of Hydrocodone and SSRIs

  • by Sungho Bea, Krista F. Huybrechts, Robert J. Glynn, Seanna M. Vine, Shruti Belitkar, Brian T. Bateman, Katsiaryna Bykov

  • November 28, 2025

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