Intravascular large B-cell lymphoma masked by multinodular goiter of the thyroid: a case report and diagnostic pitfall - Takeaways - MDSpire

Intravascular large B-cell lymphoma masked by multinodular goiter of the thyroid: a case report and diagnostic pitfall

  • By

  • Guona Zheng

  • Lei Xu

  • Lili Peng

  • Tingting Liu

  • Lin Kang

  • Huanfen Zhao

  • July 16, 2026

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  • 1

    Intravascular large B-cell lymphoma (IVLBCL) is a rare and aggressive subtype of diffuse large B-cell lymphoma, with an incidence of less than 0.5%.

  • 2

    IVLBCL can occur in the thyroid gland, but such cases are extremely rare and often lead to diagnostic challenges.

  • 3

    In this case, IVLBCL was confined to nodular goiter tissue, with no invasion of adjacent normal thyroid parenchyma or lymph nodes.

  • 4

    Initial diagnosis of the specimen was misclassified as simple nodular goiter, highlighting the risk of missed diagnosis by junior pathologists.

  • 5

    Timely diagnosis and treatment of IVLBCL are crucial, as the disease carries a poor prognosis but can be managed with standardized chemotherapy.

Original Source(s)

Intravascular large B-cell lymphoma masked by multinodular goiter of the thyroid: a case report and diagnostic pitfall

  • by Guona Zheng, Lei Xu, Lili Peng, Tingting Liu, Lin Kang, Huanfen Zhao

  • July 16, 2026

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