Purpura as the initial manifestation of IgG4-related disease with concomitant systemic lupus erythematosus: a case report - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Initial Presentation of Purpura in a Patient with Concurrent IgG4-Related Disease and Systemic Lupus Erythematosus: A Case Study

  • By

  • Yi Wei

  • Fuhua Chen

  • Ruomeng Li

  • Zhen Zhao

  • Yajuan Huang

  • June 22, 2026

Share

  • 1

    A 61-year-old man presented with purpura and was diagnosed with concurrent IgG4-related tubulointerstitial nephritis and class II lupus nephritis.

  • 2

    The patient was treated with prednisone, hydroxychloroquine, and mycophenolate mofetil, leading to resolution of purpura within one month.

  • 3

    This case highlights purpura as the initial manifestation of concurrent IgG4-related disease and systemic lupus erythematosus.

  • 4

    Renal biopsy revealed interstitial lesions with IgG4+ plasma cell infiltration and mesangioproliferative glomerulonephritis features.

  • 5

    The study provides insights into the diagnosis and management of this rare overlap syndrome involving IgG4-RD and SLE.

Original Source(s)

Purpura as the initial manifestation of IgG4-related disease with concomitant systemic lupus erythematosus: a case report

  • by Yi Wei, Fuhua Chen, Ruomeng Li, Zhen Zhao, Yajuan Huang

  • June 22, 2026

Related Content

In Vivo CAR T: A New Route to Treating Autoimmune Disease

How targeted in vivo CAR T delivery could pave the way for autoimmune disease treatments

Labial-gland artificial intelligence model screening for autoimmune thyroiditis among patients with connective tissue disease

Mechanisms of Epstein-Barr virus-associated autoimmunity: a comparative overview