Purpura as the initial manifestation of IgG4-related disease with concomitant systemic lupus erythematosus: a case report - Takeaways - MDSpire

Purpura as the initial manifestation of IgG4-related disease with concomitant systemic lupus erythematosus: a case report

  • By

  • Yi Wei

  • Fuhua Chen

  • Ruomeng Li

  • Zhen Zhao

  • Yajuan Huang

  • June 22, 2026

  • 0 min

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  • 1

    A 61-year-old man presented with purpura and was diagnosed with concurrent IgG4-related tubulointerstitial nephritis and class II lupus nephritis.

  • 2

    The patient was treated with prednisone, hydroxychloroquine, and mycophenolate mofetil, leading to resolution of purpura within one month.

  • 3

    This case highlights purpura as the initial manifestation of concurrent IgG4-related disease and systemic lupus erythematosus.

  • 4

    Renal biopsy revealed interstitial lesions with IgG4+ plasma cell infiltration and mesangioproliferative glomerulonephritis features.

  • 5

    The study provides insights into the diagnosis and management of this rare overlap syndrome involving IgG4-RD and SLE.

Original Source(s)

Purpura as the initial manifestation of IgG4-related disease with concomitant systemic lupus erythematosus: a case report

  • by Yi Wei, Fuhua Chen, Ruomeng Li, Zhen Zhao, Yajuan Huang

  • June 22, 2026

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