Survival trends in the era of novel therapies identify unmet needs in peripheral T-cell lymphoma: a national cancer database analysis - Takeaways - MDSpire

Survival trends in the era of novel therapies identify unmet needs in peripheral T-cell lymphoma: a national cancer database analysis

  • By

  • Julia Wang

  • Yajuan Gao

  • N. Nora Bennani

  • Yun Kyoung Tiger

  • Arushi Khurana

  • Urshila Durani

  • Jonas Paludo

  • Gita Thanarajasingam

  • Steven R. Hwang

  • Yucai Wang

  • Grzegorz S. Nowakowski

  • Thomas M. Habermann

  • Thomas E. Witzig

  • Stephen M. Ansell

  • Jithma P. Abeykoon

  • June 3, 2026

  • 0 min

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  • 1

    Peripheral T-cell lymphomas (PTCL) account for about 10% of non-Hodgkin lymphomas, with PTCL-NOS being the most common subtype.

  • 2

    Recent treatments have improved overall survival (OS) in PTCL, particularly in anaplastic large cell lymphoma (ALCL), but gains in PTCL-NOS and AITL remain limited.

  • 3

    Patients diagnosed in Era 2 (2012-2020) showed better OS compared to Era 1 (2004-2011), with median OS for PTCL-NOS/AITL increasing from 15.5 to 18.5 months.

  • 4

    The introduction of brentuximab vedotin significantly improved OS in ALCL, with median OS rising from 65.5 months in Era 1 to 114.5 months in Era 2.

  • 5

    Despite advancements, the overall response rates for new agents in relapsed/refractory PTCL remain modest, highlighting the need for more effective therapies.

Original Source(s)

Survival trends in the era of novel therapies identify unmet needs in peripheral T-cell lymphoma: a national cancer database analysis

  • by Julia Wang, Yajuan Gao, N. Nora Bennani, Yun Kyoung Tiger, Arushi Khurana, Urshila Durani, Jonas Paludo, Gita Thanarajasingam, Steven R. Hwang, Yucai Wang, Grzegorz S. Nowakowski, Thomas M. Habermann, Thomas E. Witzig, Stephen M. Ansell, Jithma P. Abeykoon

  • June 3, 2026

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