Long-term Effects and Anorectal Function in Patients with Anal Squamous Cell Carcinoma Following Intensity-Modulated Radiotherapy - Takeaways - MDSpire

Long-term Effects and Anorectal Function in Patients with Anal Squamous Cell Carcinoma Following Intensity-Modulated Radiotherapy

  • By

  • Tongzhen Xu

  • Jinming Shi

  • Huiying Ma

  • Jiacheng Shuai

  • Shulian Wang

  • Yongwen Song

  • Yueping Liu

  • Hui Fang

  • Ningning Lu

  • Shunan Qi

  • Bo Chen

  • Yirui Zhai

  • Wenwen Zhang

  • Hao Jing

  • Yexiong Li

  • Ning Li

  • Yuan Tang

  • Jing Jin

  • January 27, 2026

  • 0 min

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  • 1

    Intensity-modulated radiation therapy (IMRT) optimizes dose delivery for anal squamous cell carcinoma while minimizing exposure to surrounding organs.

  • 2

    A retrospective study assessed 5-year outcomes and anorectal function in patients with anal squamous cell carcinoma treated with IMRT.

  • 3

    Concurrent chemotherapy with mitomycin-C and fluoropyrimidine was administered alongside IMRT to enhance treatment efficacy.

  • 4

    Anorectal function was evaluated using multiple grading scales, including the Wexner and Vaizey scales, to assess fecal incontinence.

  • 5

    Overall survival and disease-free survival were analyzed using the Kaplan-Meier method, with statistical significance set at p < 0.05.

Original Source(s)

Long-term Effects and Anorectal Function in Patients with Anal Squamous Cell Carcinoma Following Intensity-Modulated Radiotherapy

  • by Tongzhen Xu, Jinming Shi, Huiying Ma, Jiacheng Shuai, Shulian Wang, Yongwen Song, Yueping Liu, Hui Fang, Ningning Lu, Shunan Qi, Bo Chen, Yirui Zhai, Wenwen Zhang, Hao Jing, Yexiong Li, Ning Li, Yuan Tang, Jing Jin

  • January 27, 2026

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