Association of the combined triglyceride glucose-body mass index and serum IQGAP3 in appraising coronary lesion severity in type 2 diabetes - Takeaways - MDSpire

Association of the combined triglyceride glucose-body mass index and serum IQGAP3 in appraising coronary lesion severity in type 2 diabetes

  • By

  • YuRong Sun

  • Jingsi Zhang

  • Yi Lu

  • Yeting Chang

  • Yanchun Ding

  • July 2, 2026

  • 0 min

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  • 1

    This study evaluated the relationship between serum IQGAP3 levels, TyG-BMI, and coronary lesion severity in patients with type 2 diabetes mellitus.

  • 2

    Serum IQGAP3 and TyG-BMI levels significantly increased across Gensini score tertiles, indicating a correlation with coronary stenosis severity.

  • 3

    Both IQGAP3 and TyG-BMI were independently associated with severe coronary stenosis, with specific odds ratios reported for each.

  • 4

    The combination of TyG-BMI and IQGAP3 improved the predictive accuracy for coronary lesion severity, as demonstrated by ROC curve analysis.

  • 5

    Age modified the association between IQGAP3 and severe coronary stenosis, showing a stronger effect in patients younger than 65 years.

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