Metabolic reprogramming of glutamine is associated with M2 macrophage polarization in allergic rhinitis - Takeaways - MDSpire

Metabolic reprogramming of glutamine is associated with M2 macrophage polarization in allergic rhinitis

  • By

  • Yan, Shang

  • Xue, Kai

  • Wang, Yinan

  • Jia, Desheng

  • Chen, Yong-chao

  • Lai, Xueyou

  • Zhao, Chunrui

  • Pan, Hongguang

  • Zeng, Nan

  • April 13, 2026

  • 0 min

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  • 1

    Allergic rhinitis is a type 2 immune-driven disease influenced by additional regulatory mechanisms in the immune microenvironment.

  • 2

    Elevated glutamine levels were identified in the nasal mucosa of allergic rhinitis patients, impacting immune cell function.

  • 3

    Dietary glutamine supplementation altered nasal behavioral responses in experimental models of allergic rhinitis.

  • 4

    High-glutamine conditions correlated with a transcriptional shift in macrophages toward an M2-like state.

  • 5

    FGFR1 expression and signaling were influenced by glutamine availability, linking metabolic changes to immune responses in allergic rhinitis.

Original Source(s)

Metabolic reprogramming of glutamine is associated with M2 macrophage polarization in allergic rhinitis

  • by Yan, Shang , Xue, Kai , Wang, Yinan , Jia, Desheng , Chen, Yong-chao , Lai, Xueyou , Zhao, Chunrui , Pan, Hongguang , Zeng, Nan

  • April 13, 2026

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