CD73 activity controls cytotoxic CD4 T-cell response driving myocardial pathology in chronic Chagas disease - Takeaways - MDSpire

CD73 activity controls cytotoxic CD4 T-cell response driving myocardial pathology in chronic Chagas disease

  • By

  • Gastón Bergero

  • Yanina L. Mazzocco

  • Zoé M. Cejas Gallardo

  • Walter Rivarola

  • Sebastian Del Rosso

  • Maria P. Aoki

  • May 12, 2026

  • 0 min

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  • 1

    Chagas disease, caused by Trypanosoma cruzi, is a leading cause of infectious cardiopathology globally.

  • 2

    CD73 acts as a key immunoregulator of cytotoxic CD4 T-cell responses during T. cruzi infection.

  • 3

    CD73 deficiency enhances CD4 T-cell cytotoxicity but leads to chronic cardiac inflammation and fibrosis.

  • 4

    Patients with chronic Chagas disease show increased granzyme B expression in CD4 T-cells, indicating their cytotoxic potential.

  • 5

    Purinergic signaling via CD73 is crucial for balancing immune responses and tissue damage in Chagas disease.

Original Source(s)

CD73 activity controls cytotoxic CD4 T-cell response driving myocardial pathology in chronic Chagas disease

  • by Gastón Bergero, Yanina L. Mazzocco, Zoé M. Cejas Gallardo, Walter Rivarola, Sebastian Del Rosso, Maria P. Aoki

  • May 12, 2026

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