CTS Surgery Biopsies May Identify Early ATTR-CM

Biopsy-guided screening in older patients with idiopathic carpal tunnel syndrome detected mostly early-stage, often asymptomatic disease

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Biopsy-guided screening during carpal tunnel surgery may identify transthyretin amyloid cardiomyopathy (ATTR-CM) earlier in selected older patients.
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Among 52 patients with amyloid-positive biopsies, 17% were diagnosed with ATTR-CM, mostly presenting with mild, asymptomatic disease.
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Screening detected a higher proportion of women with ATTR-CM compared to usual clinical pathways, suggesting underrecognition in routine practice.
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Patients identified through screening had less advanced disease and lower biomarker levels compared to those diagnosed clinically.
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The study highlights the potential for age- and biopsy-guided screening to detect early-stage ATTR-CM in high-risk surgical populations.

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