Impact of Sulfate-Arsenical-Ferruginous Water on Apoptosis, Oxidative Stress, and Gene Expression of Inflammatory Mediators and MicroRNA in Human Osteoarthritic Chondrocytes Stimulated by IL-1β - Takeaways - MDSpire

Impact of Sulfate-Arsenical-Ferruginous Water on Apoptosis, Oxidative Stress, and Gene Expression of Inflammatory Mediators and MicroRNA in Human Osteoarthritic Chondrocytes Stimulated by IL-1β

  • By

  • Antonella Fioravanti

  • Patrizia Manica

  • Iole Seccafico

  • Giulia Collodel

  • Elena Moretti

  • Serafino Carta

  • Sara Cheleschi

  • April 20, 2026

  • 0 min

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  • 1

    Sulfate-arsenical-ferruginous Levico water (LW) has beneficial effects on osteoarthritis (OA) through its impact on apoptosis and oxidative stress in chondrocytes.

  • 2

    LW treatment significantly counteracts IL-1β-induced cell viability loss and apoptosis in human osteoarthritic chondrocytes in a dose-dependent manner.

  • 3

    The use of 50% LW inhibited pro-inflammatory cytokines and matrix metalloproteinases while upregulating protective microRNAs in IL-1β stimulated chondrocytes.

  • 4

    Pre-incubation with BAY 11–7082, an NF-κB inhibitor, reduced IL-1β damage and enhanced the protective effects of LW on chondrocytes.

  • 5

    The study supports balneotherapy with LW as a potential treatment for OA by modulating apoptosis, oxidative stress, and inflammatory gene expression.

Original Source(s)

Impact of Sulfate-Arsenical-Ferruginous Water on Apoptosis, Oxidative Stress, and Gene Expression of Inflammatory Mediators and MicroRNA in Human Osteoarthritic Chondrocytes Stimulated by IL-1β

  • by Antonella Fioravanti, Patrizia Manica, Iole Seccafico, Giulia Collodel, Elena Moretti, Serafino Carta, Sara Cheleschi

  • April 20, 2026

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