Antibiotic therapy in necrotizing soft tissue infections: a narrative review of the greater Paris SURFAST consortium

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Necrotizing soft tissue infections (NSTIs) are rare but life-threatening, primarily affecting individuals with comorbidities.
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NSTIs are often polymicrobial, with common pathogens including streptococci and Enterobacterales, and monomicrobial infections are increasingly reported.
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Urgent management of NSTIs requires broad-spectrum antibiotics, surgical debridement, and intensive care for organ failure.
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The SURFAST consortium aims to standardize antibiotic management practices for NSTIs through a multidisciplinary approach.
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Empiric antibiotic therapy should consider risk factors for ESBL-E and MRSA infections, along with patient severity and local epidemiology.

Critical Care (Springer)

by Caroline Charlier, Bérénice Souhail, Stéphane Dauger, Paul-Louis Woerther, Alexandre Bleibtreu, Marion Caseris, Olivier Chosidow, Chloé Bertolus, Camille Hua, Gentiane Monsel, Asmaa Tazi, Tomas Urbina, Benjamin Vérillaud, Philippe Montravers, Raphaël Lepeule, Nicolas de Prost
October 10, 2025

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