Development and internal validation of a multidimensional nomogram integrating PIV, LDH, and FeNO for predicting poor asthma control in school-aged children - Takeaways - MDSpire

Development and internal validation of a multidimensional nomogram integrating PIV, LDH, and FeNO for predicting poor asthma control in school-aged children

  • By

  • Zhijian Zhan

  • Tianfu Xu

  • Saiping Huang

  • June 29, 2026

  • 0 min

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  • 1

    A nomogram was developed to predict inadequate asthma management in pediatric patients using PIV, LDH, and FeNO among other variables.

  • 2

    The study involved 232 children aged 6–14 years, assessing asthma control through the Childhood Asthma Control Test (C-ACT).

  • 3

    Independent predictors of poor asthma control included PIV, LDH, FeNO, Vitamin D, asthma duration, and FEV1% predicted.

  • 4

    The combined model demonstrated superior predictive performance with an AUC of 0.886 compared to individual biomarkers.

  • 5

    The nomogram showed good calibration and clinical net benefit, supporting its potential for personalized asthma management.

Original Source(s)

Development and internal validation of a multidimensional nomogram integrating PIV, LDH, and FeNO for predicting poor asthma control in school-aged children

  • by Zhijian Zhan, Tianfu Xu, Saiping Huang

  • June 29, 2026

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