Dana-Farber Research News 10.01.2026 - Takeaways - MDSpire
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Dana-Farber Research News 10.01.2026

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  • October 1, 2026

  • 32 min

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  • 1

    The CheckMate-274 trial shows adjuvant nivolumab nearly doubles median disease-free survival in high-risk urothelial carcinoma compared to placebo.

  • 2

    Lorlatinib demonstrates unprecedented long-term progression-free survival in advanced ALK-positive non-small-cell lung cancer after 7 years of follow-up.

  • 3

    Patients on lorlatinib without progression at 24 months have a 79% probability of survival without progression at year 7.

  • 4

    The POSITIVE trial indicates that temporary interruption of adjuvant endocrine therapy for pregnancy is feasible and safe in young women with early breast cancer.

  • 5

    Updated results from the POSITIVE trial show similar breast cancer-free and distant recurrence-free interval rates compared to the SOFT/TEXT trials.

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