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American Epilepsy Society Clinical Practice Guideline: Infantile Epilepsy
This American Epilepsy Society (AES) practice guideline provides updated, evidence-based recommendations for the management of epilepsy in infants and children aged 1 month to <36 months.
The American Epilepsy Society guideline offers updated recommendations for managing epilepsy in infants aged 1 month to <36 months.
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The guideline incorporates new evidence published between August 2021 and September 2025, updating a prior systematic review.
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Two strong surgical recommendations are made for drug-resistant epilepsy: Hemispherectomy for specific unilateral lesions and focal disconnection surgeries.
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West syndrome and infantile spasms are excluded from the guideline due to existing disorder-specific guidelines.
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The authors highlight the need for higher-quality, etiology-specific data on long-term outcomes in this vulnerable population.
