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Rising Endometrial Cancer Incidence: Clinical Priorities in Evaluation and Management
The increasing incidence of endometrial cancer is placing greater emphasis on timely recognition of abnormal uterine bleeding, individualized risk assessment and prompt diagnostic evaluation.
Endometrial cancer incidence is rising in the United States and globally, with population aging and obesity identified as important contributors.
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Any postmenopausal bleeding, including spotting, warrants evaluation; new or unexplained bleeding-pattern changes in younger patients also merit assessment.
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Initial evaluation may include bleeding history, pelvic examination and transvaginal ultrasound, but diagnosis requires endometrial tissue sampling.
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Treatment depends on histology and stage; early-stage disease may be treated with hysterectomy, while advanced disease may require multimodality therapy.
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Carefully selected patients with certain early-stage endometrioid cancers may consider fertility-sparing treatment with close surveillance.
