Laboratory biomarkers and radiographic osteolysis after total knee arthroplasty: a retrospective pilot study - Takeaways - MDSpire

Laboratory biomarkers and radiographic osteolysis after total knee arthroplasty: a retrospective pilot study

  • By

  • Lifei Wang

  • Hefang Xiao

  • Jinming Liu

  • Haotian He

  • Bao Xian

  • Bin Geng

  • Yayi Xia

  • May 22, 2026

  • 0 min

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  • 1

    This study analyzed 375 patients who underwent total knee arthroplasty (TKA) to identify risk factors for periprosthetic osteolysis.

  • 2

    Logistic regression revealed that higher leukocyte count and FIB-4 index increased the odds of osteolysis, while higher uric acid-to-creatinine ratio decreased them.

  • 3

    The study categorized patients into osteolysis (n=17) and non-osteolysis (n=358) groups based on radiographic findings.

  • 4

    Subgroup analyses indicated that associations between biomarkers and osteolysis varied by sex, age, diabetes, and hypertension status.

  • 5

    The findings suggest that leukocyte count, FIB-4 index, and uric acid-to-creatinine ratio may serve as independent risk factors for osteolysis after TKA.

Original Source(s)

Laboratory biomarkers and radiographic osteolysis after total knee arthroplasty: a retrospective pilot study

  • by Lifei Wang, Hefang Xiao, Jinming Liu, Haotian He, Bao Xian, Bin Geng, Yayi Xia

  • May 22, 2026

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