A Systematic Review and Network Meta-Analysis of Chinese Trials on Antihypertensive Medications for Managing Hyperuricemia in Hypertensive Patients - Takeaways - MDSpire

A Systematic Review and Network Meta-Analysis of Chinese Trials on Antihypertensive Medications for Managing Hyperuricemia in Hypertensive Patients

  • By

  • Juan Wu

  • Hong Di

  • Yun Zhang

  • Xuejun Zeng

  • December 2, 2025

  • 0 min

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  • 1

    Hypertension prevalence in China is 27.9%, with hyperuricemia affecting 38.7% of hypertensive patients, highlighting a significant health concern.

  • 2

    Antihypertensive medications may influence hyperuricemia, with diuretics and β-blockers potentially increasing risk, while some agents reduce it.

  • 3

    Previous reviews indicated losartan is more effective than other antihypertensive agents in lowering serum uric acid levels in hypertensive patients.

  • 4

    This systematic review and network meta-analysis aimed to synthesize evidence on the urate-lowering efficacy of various antihypertensive agents.

  • 5

    The study identified a gap in global evidence, as no non-Chinese RCTs met inclusion criteria, emphasizing the need for more diverse research.

Original Source(s)

A Systematic Review and Network Meta-Analysis of Chinese Trials on Antihypertensive Medications for Managing Hyperuricemia in Hypertensive Patients

  • by Juan Wu, Hong Di, Yun Zhang, Xuejun Zeng

  • December 2, 2025

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