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1
Gastric cancer is the fifth most commonly diagnosed cancer globally, with high incidence rates in East Asia, Eastern Europe, and South America.
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2
Peritoneal metastasis occurs in 40-50% of stage IV gastric cancer patients, significantly impacting survival and treatment outcomes.
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3
Intraperitoneal chemotherapy allows for direct drug delivery to the peritoneal cavity, potentially improving treatment efficacy for peritoneal metastases.
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4
Catheter-based normothermic intraperitoneal chemotherapy has been adapted for gastric cancer, allowing sustained regional therapy without repeated surgeries.
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5
The peritoneal–plasma barrier significantly influences drug delivery and pharmacokinetics in the treatment of peritoneal malignancies.
