Letter to the Editor Regarding “Anchored Matching-Adjusted Indirect Comparison of the Long-Term Maintenance of Efficacy of Tralokinumab and Lebrikizumab in Patients with Moderate-to-Severe Atopic Dermatitis” - Takeaways - MDSpire

Letter to the Editor Regarding “Anchored Matching-Adjusted Indirect Comparison of the Long-Term Maintenance of Efficacy of Tralokinumab and Lebrikizumab in Patients with Moderate-to-Severe Atopic Dermatitis”

  • By

  • Kim Rand

  • Kurt Gebauer

  • Yousef Binamer

  • Yung-Tsu Cho

  • Manny Papadimitropoulos

  • Chao Yang

  • Helena Agell

  • Bülent Akmaz

  • Lucia Seminario-Vidal

  • June 26, 2026

  • 0 min

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  • 1

    The analysis compared tralokinumab and lebrikizumab for long-term efficacy in moderate-to-severe atopic dermatitis using MAIC.

  • 2

    Tralokinumab and lebrikizumab had different initial response rates, with 52% for lebrikizumab and 28% for tralokinumab, indicating potential selection bias.

  • 3

    The anchored MAIC approach assumes a common comparator arm, which does not hold true for the maintenance-phase analysis of these trials.

  • 4

    Lebrikizumab has a higher binding affinity and faster steady-state concentration achievement than tralokinumab, affecting clinical response duration.

  • 5

    Post-treatment withdrawal, 56% of lebrikizumab responders maintained EASI 75, compared to 26% for tralokinumab, indicating better off-drug durability.

Original Source(s)

Letter to the Editor Regarding “Anchored Matching-Adjusted Indirect Comparison of the Long-Term Maintenance of Efficacy of Tralokinumab and Lebrikizumab in Patients with Moderate-to-Severe Atopic Dermatitis”

  • by Kim Rand, Kurt Gebauer, Yousef Binamer, Yung-Tsu Cho, Manny Papadimitropoulos, Chao Yang, Helena Agell, Bülent Akmaz, Lucia Seminario-Vidal

  • June 26, 2026

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