Lorazepam-induced full resolution of catatonia and psychosis in Parkinson’s disease with acromegaly: a case report - Takeaways - MDSpire

Lorazepam-induced full resolution of catatonia and psychosis in Parkinson’s disease with acromegaly: a case report

  • By

  • Aasal Alnafisi

  • Ghaida Alharbi

  • Rami Ahmad

  • Suhaib Radi

  • Madihah Alhubayshi

  • Ahmed AlGhamdi

  • May 4, 2026

  • 0 min

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  • 1

    Lorazepam treatment resulted in complete remission of catatonia and psychotic symptoms in a 78-year-old woman with Parkinson's disease and acromegaly.

  • 2

    The patient experienced significant neuropsychiatric symptoms after discontinuing all medications, leading to acute confusion and agitation.

  • 3

    Brain MRI revealed a pituitary macroadenoma, confirming the diagnosis of acromegaly, which can exacerbate cognitive and psychiatric symptoms.

  • 4

    Within six days of starting lorazepam, the patient showed an overall improvement of approximately 50% in her symptoms.

  • 5

    This case underscores the need to recognize catatonia and psychosis as potential complications in Parkinson's disease, especially with comorbid conditions.

Original Source(s)

Lorazepam-induced full resolution of catatonia and psychosis in Parkinson’s disease with acromegaly: a case report

  • by Aasal Alnafisi, Ghaida Alharbi, Rami Ahmad, Suhaib Radi, Madihah Alhubayshi, Ahmed AlGhamdi

  • May 4, 2026

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