Treatment as Prevention and HIV Transmission in the US - Takeaways - MDSpire
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Utilizing Antiretroviral Therapy for HIV Prevention and Transmission Reduction in the United States

  • By

  • Laura Matrajt

  • Sarah E. Stansfield

  • Mia Moore

  • Deborah J. Donnell

  • Elizabeth R. Brown

  • Myron S. Cohen

  • Dobromir Dimitrov

  • August 21, 2026

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  • 1

    Antiretroviral therapy (ART) significantly reduces sexual HIV transmission and is central to HIV prevention strategies in the US.

  • 2

    The undetectable = untransmittable (U=U) principle has been widely adopted following evidence of ART's effectiveness in viral suppression.

  • 3

    Over 20 US states are considering cuts to AIDS drug assistance programs, potentially leading to thousands of new HIV infections.

  • 4

    A deterministic model was developed to evaluate the impact of treatment as prevention (TasP) on HIV incidence and prevalence.

  • 5

    The model projects outcomes based on ART access changes and estimates new HIV acquisitions from 2026 to 2030.

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