Cigarette Smoke Exposure Attenuates T2R-Mediated Apoptosis in Head and Neck Squamous Cell Carcinoma - Takeaways - MDSpire
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Cigarette Smoke Exposure Reduces T2R-Driven Apoptosis in Head and Neck Squamous Cell Carcinoma

  • By

  • Kyle Polen

  • Sarah Sywanycz

  • Gavin Turner

  • Brianna L. Hill

  • Lily Huang

  • Zoey A. Miller

  • Casey Hanna

  • Lovely Raghav

  • Devraj Basu

  • Robert J. Lee

  • Ryan M. Carey

  • April 25, 2026

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  • 1

    Head and neck squamous cell carcinomas (HNSCCs) are commonly associated with tobacco use, impacting disease progression and survival rates.

  • 2

    Cigarette smoke exposure is linked to reduced bitter taste perception and may alter T2R expression and function in HNSCC cells.

  • 3

    T2Rs are functional receptors in HNSCC that mediate apoptosis through calcium signaling and are associated with improved patient survival.

  • 4

    Continued smoking in HNSCC patients is correlated with more aggressive disease and poorer locoregional control.

  • 5

    The study hypothesizes that cigarette smoke condensate exposure may diminish T2R-mediated apoptosis in HNSCC.

Original Source(s)

Cigarette Smoke Exposure Attenuates T2R-Mediated Apoptosis in Head and Neck Squamous Cell Carcinoma

  • by Kyle Polen, Sarah Sywanycz, Gavin Turner, Brianna L. Hill, Lily Huang, Zoey A. Miller, Casey Hanna, Lovely Raghav, Devraj Basu, Robert J. Lee, Ryan M. Carey

  • April 25, 2026

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