Successful use of outpatient parenteral antimicrobial therapy (OPAT) aztreonam–avibactam in a pediatric case of an infectious pseudoarthrosis caused by NDM-producing Klebsiella pneumoniae and Pseudomonas aeruginosa - Takeaways - MDSpire
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Effective Administration of Outpatient Parenteral Antimicrobial Therapy (OPAT) with Aztreonam–Avibactam in a Pediatric Patient with Infectious Pseudoarthrosis Due to NDM-Producing Klebsiella pneumoniae and Pseudomonas aeruginosa

  • By

  • Maite Bosch-Peligero

  • Carla Codina-Jimenez

  • Cristian Chaguaceda Galisteo

  • Clara Rodríguez-González

  • Sandra García-Xipell

  • Mireia Coll-Vinent Olle

  • Berta Sofia Fernández Ledesma

  • Jun Hao Wang-Wang

  • Jordi Joseph Vilaplana

  • Marlene Álvarez Martins

  • July 14, 2026

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  • 1

    A 9-year-old girl with war-related trauma developed infectious pseudoarthrosis of the right distal tibia caused by NDM-producing *Klebsiella pneumoniae* and *Pseudomonas aeruginosa*.

  • 2

    After initial inpatient treatment, she received off-label aztreonam-avibactam through outpatient parenteral antimicrobial therapy (OPAT).

  • 3

    Cultures identified *P aeruginosa* and ESBL- and NDM-producing *K pneumoniae*, with the latter susceptible only to gentamicin and aztreonam-avibactam.

  • 4

    The pharmacy prepared individualized aztreonam-avibactam doses for continuous home infusion using two 12-hour elastomeric pumps each day.

  • 5

    After surgery and a 6-week antimicrobial course, the patient remained clinically stable without evidence of persistent or recurrent infection at 2-month follow-up.

Original Source(s)

Successful use of outpatient parenteral antimicrobial therapy (OPAT) aztreonam–avibactam in a pediatric case of an infectious pseudoarthrosis caused by NDM-producing Klebsiella pneumoniae and Pseudomonas aeruginosa

  • by Maite Bosch-Peligero, Carla Codina-Jimenez, Cristian Chaguaceda Galisteo, Clara Rodríguez-González, Sandra García-Xipell, Mireia Coll-Vinent Olle, Berta Sofia Fernández Ledesma, Jun Hao Wang-Wang, Jordi Joseph Vilaplana, Marlene Álvarez Martins

  • July 14, 2026

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