Circular RNA circEVI5 functions as a miR-433 sponge to promote renal cell carcinoma progression via GBP2-mediated oncogenic signaling - Takeaways - MDSpire

Circular RNA circEVI5 functions as a miR-433 sponge to promote renal cell carcinoma progression via GBP2-mediated oncogenic signaling

  • By

  • Yang Xiong

  • Jin Li

  • Zhi-Peng Tang

  • Xiao Xie

  • Yu Liang

  • July 15, 2026

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  • 1

    CircEVI5 is significantly upregulated in renal cell carcinoma (RCC) tissues and cell lines, correlating with advanced tumor stage and poor survival.

  • 2

    Knockdown of circEVI5 inhibits RCC cell viability, migration, and invasion in vitro, and suppresses tumor growth in vivo.

  • 3

    CircEVI5 functions as a molecular sponge for miR-433, which is downregulated in RCC and inversely correlated with GBP2 expression.

  • 4

    GBP2 overexpression in RCC tissues predicts reduced survival, while miR-433 levels are inversely correlated with both circEVI5 and GBP2.

  • 5

    The study establishes circEVI5 as an oncogenic driver in RCC progression through the miR-433/GBP2 regulatory axis.

Original Source(s)

Circular RNA circEVI5 functions as a miR-433 sponge to promote renal cell carcinoma progression via GBP2-mediated oncogenic signaling

  • by Yang Xiong, Jin Li, Zhi-Peng Tang, Xiao Xie, Yu Liang

  • July 15, 2026

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