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1
Metastasis is the leading cause of cancer-related deaths, necessitating the development of therapies to suppress metastatic spread.
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2
Migrastatics are agents designed to disrupt cellular invasiveness by targeting the cytoskeleton, impacting cell motility and invasive processes.
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3
The toxicity associated with migrastatics has hindered their clinical application, despite their potential to prevent cancer relapse.
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4
Metastasis involves a dynamic process of dissemination, dormancy, and colonization, complicating therapeutic management.
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5
Cytoskeletal dynamics are crucial for metastasis regulation, enabling cancer cells to adapt and migrate through various environments.
