Short-term cardiotoxicity and early echocardiographic changes following autologous hematopoietic stem cell transplantation: a single-center retrospective analysis

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This study evaluates echocardiographic changes within 100 days after autologous stem cell transplantation (ASCT) in 205 patients.
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A statistically significant decline in left ventricular ejection fraction (LVEF) was observed post-ASCT, with mean LVEF decreasing from 94.1% to 91.2%.
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The prevalence of valvular abnormalities increased from 42% to 50.7% post-ASCT, indicating a rise in cardiac complications.
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Pre-existing left ventricular dysfunction was significantly associated with post-transplant LV dysfunction and valvular disease.
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The study suggests the need for early echocardiographic surveillance to detect subclinical cardiotoxicity after ASCT.

Frontiers In Cardiovascular Medicine

by Jean El Cheikh, Maria El Tannir, Ali Awada, Ali Tarhini, Nour Moukalled, Iman Abou Dalle, Omar Fakhreddine, Walid Gharzuddin, Ali Bazarbachi, Hadi Skouri
May 28, 2026

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