Overall survival and progression-free survival in pediatric meningiomas: a systematic review and individual patient-level meta-analysis

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Pediatric meningiomas (PMs) account for 1-5% of all meningiomas and differ significantly from adult meningiomas in clinical and molecular characteristics.
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The meta-analysis included 20 studies, focusing on patients aged 21 or younger with histopathologically confirmed cranial sporadic or NF-associated meningiomas.
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Mean progression-free survival (PFS) varied by age group, with younger patients (0-3 years) showing significantly shorter PFS compared to older groups.
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Overall survival (OS) did not show significant differences across age groups, with the oldest group (13-21 years) having the longest OS.
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The study highlights the need for tailored clinical practice guidelines for PMs due to their unique characteristics and treatment responses.

Journal Of Neuro-Oncology

by Johannes Wach, Martin Vychopen, Alim Emre Basaran, Marcos Tatagiba, Roland Goldbrunner, Erdem Güresir
January 9, 2025

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