Impact of Dual Antiplatelet Therapy Duration on Stent Thrombosis Risk in Patients Undergoing Complex Percutaneous Coronary Intervention: A Meta-Analysis - Takeaways - MDSpire
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Impact of Dual Antiplatelet Therapy Duration on Stent Thrombosis Risk in Patients Undergoing Complex Percutaneous Coronary Intervention: A Meta-Analysis

  • By

  • Fiorenzo Simonetti

  • Claudia Carassia

  • Hector Alfonso Alvarez Covarrubias

  • Michael Joner

  • Thorsten Kessler

  • Tobias Rheude

  • Hendrik Sager

  • Felix Voll

  • Moritz von Scheidt

  • Erion Xhepa

  • Adnan Kastrati

  • Salvatore Cassese

  • April 28, 2026

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  • 1

    Complex percutaneous coronary intervention (PCI) is increasingly performed but carries a higher risk of ischemic events, including stent thrombosis (ST).

  • 2

    Dual antiplatelet therapy (DAPT) is essential after PCI to mitigate thrombotic risks, with extended DAPT often used in complex PCI patients to prevent ST.

  • 3

    Current guidelines suggest varying DAPT durations based on hemorrhagic and ischemic risks, complicating treatment decisions for complex PCI patients.

  • 4

    This meta-analysis aims to evaluate the impact of DAPT duration on ischemic events in patients undergoing complex PCI, addressing a significant knowledge gap.

  • 5

    The study will assess primary outcomes like stent thrombosis and secondary outcomes including myocardial infarction and major bleeding in complex PCI patients.

Original Source(s)

Impact of Dual Antiplatelet Therapy Duration on Stent Thrombosis Risk in Patients Undergoing Complex Percutaneous Coronary Intervention: A Meta-Analysis

  • by Fiorenzo Simonetti, Claudia Carassia, Hector Alfonso Alvarez Covarrubias, Michael Joner, Thorsten Kessler, Tobias Rheude, Hendrik Sager, Felix Voll, Moritz von Scheidt, Erion Xhepa, Adnan Kastrati, Salvatore Cassese

  • April 28, 2026

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